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Bacterial Na+/H+ antiporter B (NhaB)
This family consists of several bacterial Na+/H+ antiporter B (NhaB) proteins. The exact function of this family is unknown [1,2]. [1]. 9518558. Topological study of Vibrio alginolyticus NhaB Na+/H+ antiporter. using gene fusions in Escherichia coli cells.. Enomoto H, Unemoto T, Nishibuchi M, Padan E, Nakamura T;. Biochim Biophys Acta 1998;1370:77-86.. [2]. 12562793. Roles of NhaA, NhaB, and NhaD Na+/H+ antiporters in survival of. Vibrio cholerae in a saline environment.. Herz K, Vimont S, Padan E, Berche P;. J Bacteriol 2003;185:1236-1244. (from Pfam)
SLC13 family permease
The SLC13 family permease is also known as DASS (Divalent Anion:Na+ Symporter). Characterized members are symporters of a substrate anion with sodium cations.
Na(+)/H(+) antiporter NhaB
Na(+)/H(+) antiporter NhaB is involved in regulation of intracellular pH under alkaline conditions
These proteins are members of the NhaB Na+:H+ Antiporter (NhaB) Family (TC 2.A.34). The only characterised member of this family is the Escherichia coli NhaB protein, which has 12 GES predicted transmembrane regions, and catalyses sodium/proton exchange. Unlike NhaA this activity is not pH dependent.
sodium/proton antiporter NhaB
Exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
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