Protein Family Models

In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein Pfam:PF04977 [3], however this interaction may be indirect [4]. [1]. 1332942. FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. Guzman LM, Barondess JJ, Beckwith J;. J Bacteriol 1992;174:7716-7728. [2]. 10986263. Analysis of the essential cell division gene ftsL of Bacillus subtilis by mutagenesis and heterologous complementation. Sievers J, Errington J;. J Bacteriol 2000;182:5572-5579. [3]. 10844672. The Bacillus subtilis cell division protein FtsL localizes to sites of septation and interacts with DivIC. Sievers J, Errington J;. Mol Microbiol 2000;36:846-855. [4]. 11994149. The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. Robson SA, Michie KA, Mackay JP, Harry E, King GF;. Mol Microbiol 2002;44:663-674. (from Pfam)

Date:

2024-10-16

cell division protein FtsL is an essential cell division protein that may link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic

Date:

2023-02-23

This model represents FtsL, both forms similar to that in E. coli and similar to that in B. subtilis. FtsL is one of the later proteins active in cell division septum formation. FtsL is small, low in complexity, and highly divergent. The scope of this model is broader than that of the Pfam model PF04999.3 for FtsL, as this one includes FtsL from Bacillus subtilis and related species.

Gene:

ftsL

Date:

2022-10-11

Membrane bound cell division protein at septum

Gene:

ftsL

Date:

2020-10-26