Protein Family Models

EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterised in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP [1,2]. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope [3]. [1]. 22140496. Computational analysis of the ESX-1 region of Mycobacterium tuberculosis: insights into the mechanism of type VII secretion system. Das C, Ghosh TS, Mande SS;. PLoS One. 2011;6:e27980. [2]. 22411983. Protein secretion and surface display in Gram-positive bacteria. Schneewind O, Missiakas DM;. Philos Trans R Soc Lond B Biol Sci. 2012;367:1123-1139. [3]. 23541477. Leaving home ain't easy: protein export systems in Gram-positive bacteria. Freudl R;. Res Microbiol. 2013;164:664-674. (from Pfam)

Date:

2024-10-16

type VII secretion protein EccB is an ATPase that is part of an ESX specialized secretion system, which is a type VII secretion system (T7SS)

Date:

2019-06-25

This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccB1, EccB2, etc. This model does not identify functionally related proteins in the Firmicutes such as Staphylococcus aureus and Bacillus anthracis.

Gene:

eccB

Date:

2024-08-07