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Neurotransmitter-gated ion-channel ligand binding domain
This family is the extracellular ligand binding domain of these ion channels [1]. This domain forms a pentameric arrangement in the known structure. [1]. 11357122. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK;. Nature 2001;411:269-276. [2]. 19917292. Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel. Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M;. J Mol Biol. 2009; [Epub ahead of print] (from Pfam)
Neurotransmitter-gated ion-channel transmembrane region
This family includes the four transmembrane helices that form the ion channel. [1]. 19917292. Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel. Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M;. J Mol Biol. 2009; [Epub ahead of print] (from Pfam)
ligand-gated ion channel
ligand-gated ion channel (LIC or LGIC) is a member of a family of neurotransmitter receptors vital for communication throughout the nervous system; similar to Mus musculus gamma-aminobutyric acid receptor subunit delta
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