Protein Family Models

FtsA is essential for bacterial cell division, and co-localises to the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains [1]. The FtsA protein contains two structurally related actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain PF02491 inserted in to the RnaseH fold PF02491 [2]. [1]. 9352931. Interactions between heterologous FtsA and FtsZ proteins at the FtsZ ring. Ma X, Sun Q, Wang R, Singh G, Jonietz EL, Margolin W;. J Bacteriol 1997;179:6788-6797. [2]. 15281131. The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies. Anantharaman V, Aravind L;. Proteins. 2004;56:795-807. (from Pfam)

Date:

2024-10-16

This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl [1]. [1]. 12758091. Cytoskeletons in prokaryotes. Mayer F;. Cell Biol Int 2003;27:429-438. (from Pfam)

Date:

2024-10-16

FtsA is essential for bacterial cell division, and co-localises to the septal ring with FtsZ. The SHS2 domain is inserted in to the RNAseH fold of FtsA [2], and is involved in protein-protein interaction [1]. [1]. 9352931. Interactions between heterologous FtsA and FtsZ proteins at the FtsZ ring. Ma X, Sun Q, Wang R, Singh G, Jonietz EL, Margolin W;. J Bacteriol 1997;179:6788-6797. [2]. 15281131. The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies. Anantharaman V, Aravind L;. Proteins. 2004;56:795-807. (from Pfam)

Date:

2024-10-16

This bacterial cell division protein interacts with FtsZ, the bacterial homolog of tubulin. It is an ATP-binding protein and shows structural similarities to actin and heat shock cognate protein 70.

Gene:

ftsA

Date:

2021-04-27

cell division protein FtsA may serve as a membrane anchor for the Z ring

Date:

2024-12-11