Protein Family Models

This family consists of several WzyE proteins which appear to be specific to Enterobacteria. Members of this family are described as putative ECA polymerases this has been found to be incorrect [1]. The function of this family is unknown. The family is a transmembrane family with up to 11 TM regions, and is necessary for the assembly of O-antigen lipopolysaccharide. [1]. 11673418. Identification of the structural gene for the TDP-Fuc4NAc:lipid II Fuc4NAc transferase involved in synthesis of enterobacterial common antigen in Escherichia coli K-12. Rahman A, Barr K, Rick PD;. J Bacteriol 2001;183:6509-6516. (from Pfam)

Date:

2024-10-16

enterobacterial common antigen polymerase may be involved in assembly of the ECA linear polysaccharide chains

Date:

2017-03-27

ECA, enterobacterial common antigen, is widespread in bacteria such as Escherichia coli and Salmonella. It occurs glycerophosphatidyl-linked on the cell surface, and in a cyclized form in the periplasm. The pathway to ECA biosynthesis shares much with O-antigen biosynthesis, so the polymerase (this protein) and the flippase are named WzyE and WzxE, after the Wzy and Wzx proteins from O-antigen systems. However, WzyE is also known as WecF.

Gene:

wzyE

Date:

2022-10-11