This domain is found N-terminal in glucokinase regulatory protein (GKRP) and related proteins. GKRP regulates glucokinase and it is activated by fructose 6-phosphate and inactivated by fructose 1-phosphate. It consists of two topologically identical SIS domains and and alpha-helical lid domain [1-4]. Paper describing PDB structure 3w0l. [1]. 23733961. Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Choi JM, Seo MH, Kyeong HH, Kim E, Kim HS;. Proc Natl Acad Sci U S A. 2013;110:10171-10176. Paper describing PDB structure 4bb9. [2]. 23621087. Crystal structure of glucokinase regulatory protein. Pautsch A, Stadler N, Lohle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG;. Biochemistry. 2013;52:3523-3531. Paper describing PDB structure 4lc9. [3]. 23957911. Structural basis for regulation of human glucokinase by glucokinase regulatory protein. Beck T, Miller BG;. Biochemistry. 2013;52:6232-6239. Paper describing PDB structure 4ly9. [4]. 24226772. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Lloyd DJ, St Jean DJ Jr, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, Chen K, Chmait S, Zhang J, Liu L, Norman MH, Andrews KL, Bartberger MD, Van G, Galbreath EJ, Vonderfecht SL, Wang M, Jordan SR, Veniant MM, Hale C;. Nature. 2013;504:437-440. Paper describing PDB structure 4lzj. [5]. 24251551. Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor. Hadi T, Hazra S, T. TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-10-16