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HigA family addiction module antitoxin
Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by Pfam model PF01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair.
helix-turn-helix transcriptional regulator
helix-turn-helix (HTH) transcriptional regulator containing a XRE (Xenobiotic Response Element) family HTH domain, similar to Proteus vulgaris antitoxin HigA that binds to its own promoter and regulates transcription of the higB/higA operon and functions as the antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB toxin
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