MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity [1]. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase [3], whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known. [1]. 16855233. YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12. Becker AK, Zeppenfeld T, Staab A, Seitz S, Boos W, Morita T, Aiba H, Mahr K, Titgemeyer F, Jahreis K;. J Bacteriol. 2006;188:5439-5449. [2]. 18359269. The mechanisms of carbon catabolite repression in bacteria. Deutscher J;. Curr Opin Microbiol. 2008;11:87-93. [3]. 22178967. Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12. Gohler AK, Staab A, Gabor E, Homann K, Klang E, Kosfeld A, Muus JE, Wulftange JS, Jahreis K;. J Bacteriol. 2012;194:1024-1035. (from Pfam)
- Date:
- 2024-10-16