Protein Family Models

Acetyl-CoA carboxylase (ACC) is a central metabolic enzyme that catalyzes the committed step in fatty acid biosynthesis: biotin- dependent conversion of acetyl-CoA to malonyl-CoA [1]. In bacteria this protein contains a small zinc finger domain. [1]. 16460018. The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL;. Biochemistry. 2006;45:1712-1722. (from Pfam)

Date:

2024-10-16

All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognised types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilise acyl-CoA as the acceptor molecule. [1]. 8366018. Primary structure of the monomer of the 12S subunit of transcarboxylase as deduced from DNA and characterization of the product expressed in Escherichia coli. Thornton CG, Kumar GK, Haase FC, Phillips NF, Woo SB, Park VM, Magner WJ, Shenoy BC, Wood HG, Samols D;. J Bacteriol 1993;175:5301-5308. [2]. 8102604. Molecular evolution of biotin-dependent carboxylases. Toh H, Kondo H, Tanabe T;. Eur J Biochem 1993;215:687-696. [3]. 12663926. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Zhang H, Yang Z, Shen Y, Tong L;. Science 2003;299:2064-2067. (from Pfam)

Date:

2024-10-16

acetyl-CoA carboxylase carboxyltransferase subunit beta (AccD) is a component of the acetyl coenzyme A carboxylase (ACC) complex that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA

Date:

2024-11-05

The enzyme acetyl-CoA carboxylase contains a biotin carboxyl carrier protein or domain, a biotin carboxylase, and a carboxyl transferase. This model represents the beta chain of the carboxyl transferase for cases in which the architecture of the protein is as in E. coli, in which the carboxyltransferase portion consists of two non-identical subnits, alpha and beta.

Gene:

accD

Date:

2021-04-27