Protein Family Models

The CcmD protein is part of a C-type cytochrome biogenesis operon [1]. The exact function of this protein is uncertain. It has been proposed that CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation [2]. This protein is found fused to CcmE in Swiss:P52224. These proteins contain a predicted transmembrane helix. [1]. 7635817. Escherichia coli genes required for cytochrome c maturation. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H;. J Bacteriol 1995;177:4321-4326. [2]. 10998170. New insights into the role of CcmC, CcmD and CcmE in the haem delivery pathway during cytochrome c maturation by a complete mutational analysis of the conserved tryptophan-rich motif of CcmC. Schulz H, Pellicioli EC, Thony-Meyer L;. Mol Microbiol 2000;37:1379-1388. (from Pfam)

Gene:

ccmD

Date:

2024-10-16

The model for this protein family describes a small, hydrophobic, and only moderately well-conserved protein, tricky to identify accurately for all of these reasons. However, members are found as part of large operons involved in heme export across the inner membrane for assembly of c-type cytochromes in a large number of bacteria. The gray zone between the trusted cutoff (13.0) and noise cutoff (4.75) includes both low-scoring examples and false-positive matches to hydrophobic domains of longer proteins.

Gene:

ccmD

Date:

2022-10-11

heme exporter protein CcmD is required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Date:

2019-09-13