Protein Family Models

This is a family of hypothetical bacterial proteins found in the vicinity of Molybdenum ABC transporter ATP-binding gene-products MobA MobB and MobC. However the function could not be confirmed. This family appears to belong to the P-loop superfamily by alignment to Pfam:PF03266. However, the characteristic P-loop sequence motif appears to have diverged beyond recognition in this family. (from Pfam)

Date:

2024-08-14

This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [1]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [2]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [3]. [1]. 14503925. Thermophile-specific proteins: the gene product of aq_1292 from. Aquifex aeolicus is an NTPase.. Klinger C, Rossbach M, Howe R, Kaufmann M;. BMC Biochem. 2003;4:12.. [2]. 15777481. Crystal structure of THEP1 from the hyperthermophile Aquifex. aeolicus: a variation of the RecA fold.. Rossbach M, Daumke O, Klinger C, Wittinghofer A, Kaufmann M;. BMC Struct Biol. 2005;5:7.. [3]. 17291528. NMR structure and functional characterization of a human. cancer-related nucleoside triphosphatase.. Placzek WJ, Almeida MS, Wuthrich K;. J Mol Biol. 2007;367:788-801. (from Pfam)

Date:

2024-08-14

DUF2478 domain-containing protein

Date:

2020-07-14