Protein Family Models

This domain found associated with Pfam:PF00732. (from Pfam)

Date:

2024-08-14

This family of proteins bind FAD as a cofactor. (from Pfam)

Date:

2024-08-14

oxygen-dependent choline dehydrogenase catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate

Date:

2023-02-27

Catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine

Date:

2021-08-25

Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli [1], Staphylococcus xylosus [2], and Sinorhizobium meliloti [3], this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase [4]. This enzyme is a member of the GMC oxidoreductase family (PF00732 and PF05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase [5]. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified.

Gene:

betA

Date:

2021-04-27