Protein Family Models

PMT_4TMC is the C-terminal four membrane-pass region of protein-O-mannosyltransferases and similar enzymes. (from Pfam)

Date:

2024-08-14

This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109. These proteins are responsible for O-linked glycosylation of proteins, they catalyse the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein. Also in this family is Swiss:Q94891 Drosophila rotated abdomen protein which is a putative mannosyltransferase [2]. This family appears to be distantly related to Pfam:PF02516 (A Bateman pers. obs.). This family also contains sequences from ArnTs (4-amino-4-deoxy-L-arabinose lipid A transferase). They catalyse the addition of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to the lipid A moiety of the lipopolysaccharide [4]. This is a critical modification enabling bacteria (e.g. Escherichia coli and Salmonella typhimurium) to resist killing by antimicrobial peptides such as polymyxins [5]. Members such as Swiss:O52327 are predicted to have 12 trans-membrane regions. The N-terminal portion of these proteins is hypothesised to have a conserved glycosylation activity which is shared between distantly related oligosaccharyltransferases ArnT and PglB families [4]. [1]. 8918452. The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital. Gentzsch M, Tanner W;. EMBO J 1996;15:5752-5759. [2]. 8650217. Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila. Martin-Blanco E, Garcia-Bellido A;. Proc Natl Acad Sci U S A 1996;93:6048-6052. [3]. 7852348. Protein O-glycosylation in yeast. The PMT2 gene specifies a second protein O-mannosyltransferase that functions in addition to the PM. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

dolichyl-phosphate-mannose--protein mannosyltransferase is a glycosyltransferase family 39 protein that transfers mannosyl residues to the hydroxyl group of serine or threonine residues, initiating the assembly of O-mannosyl glycans

Date:

2019-04-24