Protein Family Models

This domain is found at the C-terminus of a variety of large catalase enzymes from bacteria. Structurally it is related to class I glutamine amidotransferase domains. The precise molecular function of this domain is uncertain. [1]. 10488114. Mutants that alter the covalent structure of catalase hydroperoxidase II from Escherichia coli. Mate MJ, Sevinc MS, Hu B, Bujons J, Bravo J, Switala J, Ens W, Loewen PC, Fita I;. J Biol Chem. 1999;274:27717-27725. [2]. 11455600. Substrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli. Melik-Adamyan W, Bravo J, Carpena X, Switala J, Mate MJ, Fita I, Loewen PC;. Proteins. 2001;44:270-281. [3]. 7663946. Crystal structure of catalase HPII from Escherichia coli. Bravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC, Fita I;. Structure. 1995;3:491-502. [4]. 12777389. An electrical potential in the access channel of catalases enhances catalysis. Chelikani P, Carpena X, Fita I, Loewen PC;. J Biol Chem. 2003;278:31290-31296. [5]. 21332158. Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli. Jha V, Louis S, Chelikani P, Carpena X, Donald LJ, Fita I, Loewen PC;. Biochemistry. 2011;50:2101-2110. [6]. 22172685. Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli leads to side chain damage and main chain cleavage. Jha V, Donald LJ, Loewen PC;. Arch Biochem Biophys. 2012;525:207-214. [7]. 24223139. Post-transcriptional regulator Hfq binds catalase HPII: crystal structure of the complex. Yonekura K, Watanabe M, Kageyama Y, Hirata K, Yamamoto M, Maki-Yonekura S;. PLoS One. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects [1]. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [2]. [1]. 11351128. Mitochondrial catalase and oxidative injury. Bai J, Cederbaum AI;. Biol Signals Recept 2001;10:189-199. [2]. 15585332. Do Th1 or Th2 sequence motifs exist in proteins? Identification of amphipatic immunomodulatory domains in Helicobacter pylori catalase. Guy B, Krell T, Sanchez V, Kennel A, Manin C, Sodoyer R;. Immunol Lett. 2005;96:261-275. (from Pfam)

Date:

2024-10-16

The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. [1]. 8626329. Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus. Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RM;. J Bacteriol 1996;178:2605-2612. [2]. 15784968. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S;. Biosci Biotechnol Biochem. 2005;69:431-439. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

hydroperoxidase II (catalase) catalyzes the dismutation of hydrogen peroxide (H2O2) to water and oxygen

Date:

2018-09-17

Monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide

Gene:

katE

Date:

2021-08-23