Protein Family Models

Sequences belonging to this family include C-terminal extension regions shared by members of the FxsB family of radical SAM/SPASM proteins that perform post-translational modifications to FxSxx-COOH family RiPP precursor proteins, but also additional proteins from bacteria that lack an FxSxx-COOH modification system. All seed alignment members, and all family members that are not fused to a radical SAM domain, have a HEXXH motif that hinted at metalloprotease activity. However, the domain recently was shown instead to function as an alpha-ketoglutarate (aKG)-dependent non-heme iron beta-hydroxylase ('H') domain. Note that this HMM has been shortened to a new length of 177 residues, from its original definition as a domain of length 399.

Date:

2024-10-01