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tRNA pseudouridine synthase
Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis. [1]. 9585540. Transfer RNA-pseudouridine synthetase Pus1 of Saccaromyces cerevisiae contains one atom of zinc essential for its native conformation and tRNA recognition. Arluison V, Hountondji C, Robert B, Grosjean H;. Biochemistry 1998;37:7268-7276. (from Pfam)
tRNA pseudouridine synthase A
tRNA pseudouridine synthase A catalyzes the formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
tRNA pseudouridine(38-40) synthase TruA
Members of this family are the tRNA modification enzyme TruA, tRNA pseudouridine(38-40) synthase. In a few species (e.g. Bacillus anthracis), TruA is represented by two paralogs.
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