Protein Family Models

The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein [1] (Sec65 in yeast [2,3]). [1]. 2460823. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Lingelbach K, Zwieb C, Webb JR, Marshallsay C, Hoben PJ, Walter P, Dobberstein B;. Nucleic Acids Res 1988;16:9431-9442. [2]. 1313947. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity. Hann BC, Stirling CJ, Walter P;. Nature 1992;356:532-533. [3]. 1313948. The S. cerevisiae SEC65 gene encodes a component of yeast signal recognition particle with homology to human SRP19. Stirling CJ, Hewitt EW;. Nature 1992;356:534-537. (from Pfam)

Date:

2024-10-16

protein similar to signal recognition particle 19 kDa protein

Date:

2017-03-02