Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Arginine repressor, C-terminal domain
This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization [1,2]. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 9334747. Solution structure of the DNA-binding domain and model for the complex of multifunctional hexameric arginine repressor with DNA. Sunnerhagen M, Nilges M, Otting G, Carey J;. Nat Struct Biol 1997;4:819-826. [2]. 11856827. The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis. Dennis C CA, Glykos NM, Parsons MR, Phillips SE;. Acta Crystallogr D Biol Crystallogr. 2002;58:421-430. (from Pfam)
Arginine repressor, DNA binding domain
arginine repressor
arginine repressor regulates arginine biosynthesis genes
This HMM includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs.
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on