The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase [3][4]. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes. [1]. 8943016. The highly conserved skb1 gene encodes a protein that interacts. with Shk1, a fission yeast Ste20/PAK homolog.. Gilbreth M, Yang P, Wang D, Frost J, Polverino A, Cobb MH,. Marcus S;. Proc Natl Acad Sci U S A 1996;93:13802-13807.. [2]. 9843966. Negative regulation of mitosis in fission yeast by the shk1. interacting protein skb1 and its human homolog, Skb1Hs.. Gilbreth M, Yang P, Bartholomeusz G, Pimental RA, Kansra S,. Gadiraju R, Marcus S;. Proc Natl Acad Sci U S A 1998;95:14781-14786.. [3]. 10531356. The human homologue of the yeast proteins Skb1 and Hsl7p. interacts with Jak kinases and contains protein. methyltransferase activity.. Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL, Pestka S;. J Biol Chem 1999;274:31531-31542.. [4]. 11152681. Prmt5, which forms distinct homo-oligomers, is a member of the. protein-arginine methyltransferase family.. Rho J, Choi S, Seong YR, Cho WK, Kim SH, Im DS;. J Biol Chem 2001;276:11393-11401. (from Pfam)
- Date:
- 2024-08-14