Protein Family Models

This family represents a distinct class of BACON domains found in crAss-like phages, the most common viral family in the human gut, in which they are found in tail fiber genes. This suggests they may play a role in phage-host interactions. [1]. 31766550. Evolution of BACON Domain Tandem Repeats in crAssphage and Novel Gut Bacteriophage Lineages. Jonge PA, Meijenfeldt FABV, Rooijen LEV, Brouns SJJ, Dutilh BE;. Viruses. 2019; [Epub ahead of print] (from Pfam)

Date:

2024-10-31

The BACON (Bacteroidetes-Associated Carbohydrate-binding Often N-terminal) domain is an all-beta domain found in diverse architectures, principally in combination with carbohydrate-active enzymes and proteases. These architectures suggest a carbohydrate-binding function which is also supported by the nature of BACON's few conserved amino-acids. The phyletic distribution of BACON and other data tentatively suggest that it may frequently function to bind mucin [1]. Further work with the characterised structure of a member of glycoside hydrolase family 5 enzyme, PDB:3ZMR, has found no evidence for carbohydrate-binding for this domain [2]. [1]. 20416301. Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module. Mello LV, Chen X, Rigden DJ;. FEBS Lett. 2010;584:2421-2426. [2]. 24463512. A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes. Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O, Klinter S, Pudlo NA, Urs K, Koropatkin NM, Creagh AL, Haynes CA, Kelly AG, Cederholm SN, Davies GJ, Martens EC, Brumer H;. Nature. 2014;506:498-502. (from Pfam)

Date:

2024-10-16

Members of Merops family M43 of zinc metalloproteases include pregnancy-associated plasma protein A (PAPP-A) in human, ulilysin in archaea, and mirolysin in the oral pathogen Tannerella forsythia, a bacterium. Many members of the family are lipoproteins.

Date:

2024-10-16

Members of this protein family are zinc-dependent metalloproteinases, related to ulilysin and other members of the pappalysin family. Members occur as predicted lipoproteins and occur mostly in the genera Bacteriodes and Prevotella.

Date:

2021-04-27

BACON and ZnMc_pappalysin_like domain-containing protein

Date:

2017-03-02