Protein Family Models

This entry represents the first three-helix domain (HTH-like) found in RecX family of proteins. RecX functions as a regulator of DNA recombination and repair pathways in bacterial cells [1]. RecX protein is known to inhibit the activity of RecA protein in DNA recombination [2,3]. [1]. 23284295. RecX facilitates homologous recombination by modulating RecA activities. Cardenas PP, Carrasco B, Defeu Soufo C, Cesar CE, Herr K, Kaufenstein M, Graumann PL, Alonso JC;. PLoS Genet. 2012;8:e1003126. [2]. 35730924. A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions. Alekseev A, Pobegalov G, Morozova N, Vedyaykin A, Cherevatenko G, Yakimov A, Baitin D, Khodorkovskii M;. Elife. 2022;11:e78409. [3]. 18650935. Structural basis for inhibition of homologous recombination by the RecX protein. Ragone S, Maman JD, Furnham N, Pellegrini L;. EMBO J. 2008;27:2259-2269. (from Pfam)

Date:

2024-10-16

regulatory protein RecX modulates RecA activities (both recombinase and coprotease) through direct physical interaction

Date:

2024-11-15