This short domain is found in many different glycosyl hydrolase enzymes, representing the carbohydrate-binding module family 5/12, including proteins such as chitinase A1, chitinase B, and endoglucanase. The domain has a carbohydrate-binding function and contains six aromatic groups that may be important for binding. These modules have a core structure consisting of a 3-stranded meander beta-sheet [1-5]. [1]. 10788483. Solution structure of the chitin-binding domain of Bacillus. circulans WL-12 chitinase A1.. Ikegami T, Okada T, Hashimoto M, Seino S, Watanabe T, Shirakawa. M;. J Biol Chem. 2000;275:13654-13661.. Paper describing PDB structure 1wvu. [2]. 16516924. Structural studies of a two-domain chitinase from Streptomyces. griseus HUT6037.. Kezuka Y, Ohishi M, Itoh Y, Watanabe J, Mitsutomi M, Watanabe T,. Nonaka T;. J Mol Biol. 2006;358:472-484.. Paper describing PDB structure 2d49. [3]. 16567413. Identification of the substrate interaction region of the. chitin-binding domain of Streptomyces griseus chitinase C.. Akagi K, Watanabe J, Hara M, Kezuka Y, Chikaishi E, Yamaguchi T,. Akutsu H, Nonaka T, Watanabe T, Ikegami T;. J Biochem. 2006;139:483-493.DR CAZY; CBM5;. Paper describing PDB structure 2rts. [4]. 24272751. Solution structure of the chitin-binding domain 1 (ChBD1) of a. hyperthermophilic chitinase from Pyrococcus furiosus.. Mine S, Nakamura T, Sato T, Ikegami T, Uegaki K;. J Biochem. 2014;155:115-122.. [5]. 25479092. Structure-based analysis of domain function of chitin. oligosaccharide deacetylase from Vibrio parahaemolyticus.. Hirano T, Sugiyama K, Sakaki Y, Hakamata W, Park SY, Nishio T;. FEBS Lett.. TRUNCATED at 1650 bytes (from Pfam)
GO Terms:- Molecular Function:
- hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
- Cellular Component:
- extracellular region (GO:0005576)
- Biological Process:
- carbohydrate metabolic process (GO:0005975)
- Molecular Function:
- carbohydrate binding (GO:0030246)
- Date:
- 2024-08-14