Protein Family Models

This family represents a crp-like helix-turn-helix domain that is likely to bind DNA. (from Pfam)

Date:

2024-08-14

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. [1]. 9068629. The Salmonella typhimurium mar locus: molecular and genetic analyses and assessment of its role in virulence. Sulavik MC, Dazer M, Miller PF;. J Bacteriol 1997;179:1857-1866. [2]. 11473263. The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF;. Nat Struct Biol 2001;8:710-714. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 7513422. Cyclic nucleotide-gated channels: an expanding new family of ion channels. Yau KW;. Proc Natl Acad Sci USA 1994;91:3481-3483. (from Pfam)

Date:

2024-10-16

Crp/Fnr family transcriptional regulator containing a DNA-binding Crp-like helix-turn-helix (HTH) domain, may bind cyclic nucleotides

Date:

2024-04-11