Protein Family Models

This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces [1]. This family Rz1 and the Rz protein Rz (Pfam:PF03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway [2]. [1]. 10651816. Membrane fusion by proline-rich Rz1 lipoprotein, the bacteriophage lambda Rz1 gene product. Bryl K, Kedzierska S, Laskowska M, Taylor A;. Eur J Biochem 2000;267:794-799. [2]. 10628848. Complementation and characterization of the nested Rz and Rz1 reading frames in the genome of bacteriophage lambda. Zhang N, Young R;. Mol Gen Genet. 1999;262:659-667. (from Pfam)

Gene:

rz1

Date:

2024-11-14

Rz1 family lipoprotein similar to bacteria and phage lipoprotein Rz1, which is a proline-rich lipoprotein from bacteriophage lambda that is known to have fusogenic properties

Date:

2020-11-03