Protein Family Models for Protein (Select 501934246) - Protein Family Models

Select item 4233681.

This domain is part of the barrel sandwich hybrid superfamily. It is found at the N-terminus of the RnfC Electron transport complex protein. It appears to be most related to the N-terminal NQRA domain (Pfam:PF05896). (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024768.5
Method:: HMM

Select item 4223202.

biotin/lipoyl-binding protein

Date:: 2024-08-14

Family Accession:: NF024923.5
Method:: HMM

Select item 4131973.

Conserved carboxylase domain

This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (Pfam:PF00682) and often close to the biotin_lipoyl domain (Pfam:PF00364) of biotin requiring enzymes. [1]. 9478969. Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum strain deltaH. Mukhopadhyay B, Stoddard SF, Wolfe RS;. J Biol Chem 1998;273:5155-5166. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF014489.5
Method:: HMM

Select item 4121334.

Glycine cleavage H-protein

This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. [1]. 8197146. X-ray structure determination at 2.6-A resolution of a lipoate- containing protein: the H-protein of the glycine decarboxylase complex from pea leaves. Pares S, Cohen-Addad C, Sieker L, Neuburger M, Douce R;. Proc Natl Acad Sci U S A 1994;91:4850-4853. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013743.5
Method:: HMM

Select item 4116605.

HMGL-like

This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-11-05

Family Accession:: NF012885.5
Method:: HMM

Select item 4109986.

biotin/lipoyl-containing protein

This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012584.5
Method:: HMM

Select item 4002047.