This family contains lipoproteins from the Lyme disease spirochete Borrelia burgdorferi and related bacteria. This entry contains proteins from Paralogous family 54 (PFam54) and 60 and (PFam60). The first crystal structure of B. burgdorferi PFam54 member BBA68 revealed a previously unseen novel fold, which, according to the CATH protein domain classification, was named the Bbcrasp-1 fold because of the common name used for the protein BBA68 [2]. [1]. 10456881. Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi. Skare JT, Foley DM, Hernandez SR, Moore DC, Blanco DR, Miller JN, Lovett MA;. Infect Immun 1999;67:4407-4417. [2]. 15711564. A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM;. Nat Struct Mol Biol. 2005;12:276-277. [3]. 32135236. Structural analysis of the outer surface proteins from Borrelia burgdorferi paralogous gene family 54 that are thought to be the key players in the pathogenesis of Lyme disease. Brangulis K, Akopjana I, Petrovskis I, Kazaks A, Tars K;. J Struct Biol. 2020; [Epub ahead of print] (from Pfam)
- Date:
- 2024-10-16