Protein Family Models

ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the Pfam:PF01580 domains in the YukA-like proteins [1]. [1]. 11973144. The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?. Pallen MJ;. Trends Microbiol 2002;10:209-212. [2]. 15657139. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Burts ML, Williams WA, DeBord K, Missiakas DM;. Proc Natl Acad Sci U S A. 2005;102:1169-1174. [3]. 19674902. Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria. Desvaux M, Hebraud M, Talon R, Henderson IR;. Trends Microbiol. 2009;17:338-340. [4]. 20852931. New insights into the distribution of WXG100 protein secretion systems. Sutcliffe IC;. Antonie Van Leeuwenhoek. 2011;99:127-131. [5]. 19299134. Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. Desvaux M, Hebraud M, Talon R, Henderson IR;. Trends Microbiol. 2009;17:139-145. (from Pfam)

Date:

2024-10-16

WXG100 family type VII secretion target similar to mycobacterial ESAT-6-like protein EsxB, also called CFP-10, which is a secreted protein that acts as a strong host T-cell antigen and is involved in the translocation of bacteria from the host phagolysosome to the host cytoplasm

Date:

2023-05-09

Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from PF06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.

Date:

2024-08-07