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glutamate-cysteine ligase family protein
Most members of this family are glutamate-cysteine ligases. but the family also includes members such as YbdK from Escherichia coli K-12, a carboxylate-amine ligase whose glutamate-cysteine ligase activity is weak and may not be its physiologically relevant activity.
glutamate--cysteine ligase
YbdK family carboxylate-amine ligase
This family represents a division of a larger family, the other branch of which is predicted to act as glutamate--cysteine ligase (the first of two enzymes in glutathione biosynthesis) in the cyanobacteria. Species containing this protein, however, are generally not believe to make glutathione, and the function is unknown.
glutamate--cysteine ligase 2 acts as ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
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