Protein Family Models for Protein (Select 499622046) - Protein Family Models

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Items: 5

Select item 4233311.

LiaF domain-containing protein

This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, LiaF, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus [2]. This domain has been described as toast rack from its structural resemblance. [1]. 16923071. The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus. Boyle-Vavra S, Yin S, Daum RS;. FEMS Microbiol Lett. 2006;262:163-171. [2]. 19889788. Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF/VraSR. Kato Y, Suzuki T, Ida T, Maebashi K;. J Antimicrob Chemother. 2010;65:37-45. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF021443.5
Method:: HMM

Select item 3966012.

new record, indexing in progress

Family Accession:

Select item 3549483.

new record, indexing in progress

Family Accession:

Select item 3354024.

cell wall-active antibiotics response protein LiaF

This HMM represents the conserved C-terminal domain of LiaF (called VraT in Staphylococcus), an additional key component of the histidine kinase LiaS and response regulator LiaR system. The system responds to cell envelop stress in the Firmicutes, and plays a role in resistance to cell wall-targeting antibiotics.