Protein Family Models

This domain is found in TagH from Staphylococcus epidermidis, the ATPase subunit of the two-component transporter TagGH, which is involved in the synthesis of bacterial polysaccharides-wall teichoic acids. This entry represents the middle SH3-like subdomain that consists of a twisted antiparallel beta-sheet and two beta-hairpins tightly packed forming a barrel structure [1]. It is usually found C-terminal to Pfam:PF00005 and N-terminal to Pfam:PF22096. Paper describing PDB structure 5bnd. [1]. 27213893. SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function. Ko TP, Tseng ST, Lai SJ, Chen SC, Guan HH, Shin Yang C, Jung Chen C, Chen Y;. Proteins. 2016;84:1328-1332. (from Pfam)

Date:

2024-10-16

TagH is the ATPase subunit of the two-component transporter TagGH involved in the synthesis of bacterial polysaccharides-wall teichoic acids. This entry represents the C-terminal of TagH that adopts an alpha/beta structure consisting of a central antiparallel mixed beta-sheet packed on one side with helices [1]. It is anticipated that this domain is involved in the binding to negatively charged polymer. Paper describing PDB structure 5bnd. [1]. 27213893. SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function. Ko TP, Tseng ST, Lai SJ, Chen SC, Guan HH, Shin Yang C, Jung Chen C, Chen Y;. Proteins. 2016;84:1328-1332. (from Pfam)

Date:

2024-10-16

ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains. [1]. 1864505. Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Rosteck PR Jr, Reynolds PA, Hershberger CL;. Gene 1991;102:27-32. [2]. 1977073. Structure and function of haemolysin B,P-glycoprotein and other members of a novel family of membrane translocators. Blight MA, Holland IB;. Mol Microbiol 1990;4:873-880. [3]. 2229036. Binding protein-dependent transport systems. Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP;. J Bioenerg Biomembr 1990;22:571-592. [4]. 9872322. Crystal structure of the ATP-binding subunit of an ABC transporter. Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH;. Nature 1998;396:703-707. (from Pfam)

Date:

2024-10-16