Protein Family Models for Protein (Select 499290999) - Protein Family Models

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
UI List

Sort by

Default order
Publication Date (up)
Publication Date (down)

Send to:

Choose Destination

File
Clipboard
Collections

Links from Protein

Items: 4

Select item 4133971.

Platelet-activating factor acetylhydrolase, isoform II

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in Pfam:PF02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted. [1]. 9645224. The structure and function of platelet-activating factor acetylhydrolases. Derewenda ZS, Derewenda U;. Cell Mol Life Sci 1998;54:446-455. [2]. 9218411. Platelet-activating factor acetylhydrolases. Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM;. J Biol Chem 1997;272:17895-17898. (from Pfam)

GO Terms:

Molecular Function:: 1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847)

Biological Process:: lipid catabolic process (GO:0016042)

Date:: 2024-11-04

Family Accession:: NF015368.5
Method:: HMM

Select item 3895192.

new record, indexing in progress

Family Accession:

Select item 3491343.

new record, indexing in progress

Family Accession:

Select item 1956504.

alpha/beta hydrolase family protein

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad