Protein Family Models for Protein (Select 499171829) - Protein Family Models

Select item 4272041.

AAA family ATPase

GO Terms:

Biological Process:: double-strand break repair (GO:0006302)

Molecular Function:: ATP hydrolysis activity (GO:0016887)

Date:: 2024-08-14

Family Accession:: NF024867.5
Method:: HMM

Select item 4236252.

AAA family ATPase

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024573.5
Method:: HMM

Select item 4220313.

AAA family ATPase

Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Molecular Function:: ATP hydrolysis activity (GO:0016887)

Date:: 2024-08-14

Family Accession:: NF024700.5
Method:: HMM

Select item 4164634.

SMC proteins Flexible Hinge Domain

This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ([1]). [1]. 12411491. Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. Hirano M, Hirano T;. EMBO J 2002;21:5733-5744. (from Pfam)

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Molecular Function:: ATP binding (GO:0005524)

Cellular Component:: chromosome (GO:0005694)

Biological Process:: chromosome organization (GO:0051276)

Date:: 2024-10-16

Family Accession:: NF018208.5
Method:: HMM

Select item 4139865.

RecF/RecN/SMC N terminal domain

This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination. [1]. 10429180. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, Jessberger R;. Eur J Biochem 1999;263:6-13. [2]. 9640531. SMC protein complexes and higher-order chromosome dynamics. Hirano T;. Curr Opin Cell Biol 1998;10:317-322. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF014516.5
Method:: HMM

Select item 4010756.