Protein Family Models for Protein (Select 498361938) - Protein Family Models

Select item 4263801.

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme. [1]. 16154095. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Chappie JS, Canaves JM, Han GW, Rife CL, Xu Q, Stevens RC;. Structure. 2005;13:1385-1396. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF036998.5
Method:: HMM

Select item 4139502.

Nicotinate phosphoribosyltransferase (NAPRTase) family

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase Pfam:PF01729. [1]. 10825532. Salvage pathway for NAD biosynthesis in Brevibacterium ammoniagenes: regulatory properties of triphosphate-dependent nicotinate phosphoribosyltransferase. Dulyaninova NG, Podlepa EM, Toulokhonova1 LV, Bykhovsky VY;. Biochim Biophys Acta 2000;1478:211-220. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF016021.5
Method:: HMM

Select item 4077323.

new record, indexing in progress

Family Accession:

Select item 3913144.

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Family Accession:

Select item 3612985.

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Family Accession:

Select item 3507636.

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Family Accession:

Select item 1419007.

nicotinate phosphoribosyltransferase

This HMM represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513).

Gene:: pncB

GO Terms:

Molecular Function:: nicotinate phosphoribosyltransferase activity (GO:0004516)

Biological Process:: NAD biosynthetic process (GO:0009435)

Date:: 2024-06-11

Family Accession:: TIGR01514.1
Method:: HMM

Select item 1367438.

nicotinate phosphoribosyltransferase

nicotinate phosphoribosyltransferase (NAPRTase) catalyzes the first and rate limiting step of the NAD salvage pathway, the formation of nicotinic acid mononucleotide (NAMN) and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid

Date:: 2024-11-19

Family Accession:: 10012319
Method:: Sparcle

Select item 343459.

nicotinate phosphoribosyltransferase

Catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate

Date:: 2020-10-26

Family Accession:: NF003704.0
Method:: HMM

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