Protein Family Models

This entry represents the C-terminal helix-turn-helix like domain from the T. brucei kRNA editing factor MRB1590 [1]. Paper describing PDB structure 4yix. [1]. 26117548. Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. Shaw PL, McAdams NM, Hast MA, Ammerman ML, Read LK, Schumacher MA;. Nucleic Acids Res. 2015;43:7096-7109. (from Pfam)

Date:

2024-10-16

This is the N-terminal domain of various bacterial predicted ABC class ATPases which shows sequence and structural similarities to the N-terminal domain of MRB1590 (swiss:Q57ZF2) from kinetoplastids, a core protein of the multiprotein mitochondrial RNA binding complex 1 (MRB1) involved in kinetoplastid RNA (kRNA) editing [1]. MRB1590 is a dimer and contains a central ABC ATPase fold (Pfam:PF09818) between novel N- and C-terminal regions. The N-terminal domains combine and form a RNA-binding basic pore which involves an arginine patch that has been suggested to act as a chaperone to bind and stabilize ssRNA during kRNA editing processes. N-terminal MRB1590 shows structural similarity to chaperones [1]. [1]. 26117548. Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. Shaw PL, McAdams NM, Hast MA, Ammerman ML, Read LK, Schumacher MA;. Nucleic Acids Res. 2015;43:7096-7109. (from Pfam)

Date:

2024-10-16

This is the C-terminal ATPase domain from bacterial ABC class ATPases. This entry also includes MRB1590 (Swiss:Q57ZF2) from Trypanosoma brucei brucei has a central ATPase domain homologous to this domain [1]. [1]. 26117548. Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. Shaw PL, McAdams NM, Hast MA, Ammerman ML, Read LK, Schumacher MA;. Nucleic Acids Res. 2015;43:7096-7109. (from Pfam)

Date:

2024-10-16

ABC-ATPase domain-containing protein similar to Trypanosoma brucei kinetoplastid RNA (kRNA) editing factor MRB1590 that binds RNA

Date:

2019-06-28