Protein Family Models

The founder member of this family is S. aureus sortase, a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall [1]. [1]. 10427003. Staphylococcus aureus sortase, an enzyme that anchors surface. proteins to the cell wall.. Mazmanian SK, Liu G, Ton-That H, Schneewind O;. Science 1999;285:760-763.. [2]. 11239768. An embarrassment of sortases - a richness of substrates?. Pallen MJ, Lam AC, Antonio M, Dunbar K;. Trends Microbiol 2001;9:97-102. (from Pfam)

Date:

2024-08-14

class B sortase is a membrane-bound cysteine transpeptidase which cleaves its surface protein substrate at a conserved cell wall sorting signal and covalently links it to peptidoglycan, and also functions as a pilin polymerase responsible for the assembly of pili

Date:

2016-05-13

Members of this transpeptidase family are, in most cases, designated sortase B, product of the srtB gene. This protein shows only distant similarity to the sortase A family, for which there may be several members in a single bacterial genome. Typical SrtB substrate motifs include NAKTN, NPKSS, etc, and otherwise resemble the LPXTG sorting signals recognized by sortase A proteins.

Gene:

srtB

Date:

2021-05-12