Protein Family Models

Date:

2024-08-14

NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation. [1]. 8895556. Crystal structure of NH3-dependent NAD+ synthetase from Bacillus. subtilis.. Rizzi M, Nessi C, Mattevi A, Coda A, Bolognesi M, Galizzi A;. EMBO J 1996;15:5125-5134. (from Pfam)

Date:

2024-08-14

This domain is found in phosphoadenosine phosphosulfate (PAPS) reductase enzymes or PAPS sulfotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases [1]. The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) [1,2]. It is also found in NodP nodulation protein P from Rhizobium which has ATP sulfurylase activity (sulfate adenylate transferase) [3]. [1]. 9261082. Crystal structure of phosphoadenylyl sulphate (PAPS) reductase:. a new family of adenine nucleotide alpha hydrolases.. Savage H, Montoya G, Svensson C, Schwenn JD, Sinning I;. Structure 1997;5:895-906.. [2]. 7588765. Reaction mechanism of thioredoxin: 3'-phospho-adenylylsulfate. reductase investigated by site-directed mutagenesis.. Berendt U, Haverkamp T, Prior A, Schwenn JD;. Eur J Biochem 1995;233:347-356.. [3]. 2250719. ATP sulphurylase activity of the nodP and nodQ gene products of. Rhizobium meliloti.. Schwedock J, Long SR;. Nature 1990;348:644-647. (from Pfam)

Date:

2024-08-14

This family of proteins belongs to the PP-loop superfamily [1]. [1]. 7731953. A P-loop-like motif in a widespread ATP pyrophosphatase domain:. implications for the evolution of sequence motifs and enzyme. activity.. Bork P, Koonin EV;. Proteins 1994;20:347-355. (from Pfam)

Date:

2024-08-14

Date:

2024-05-30