Protein Family Models

Isopentenyl transferase / dimethylallyl transferase synthesises isopentenyladensosine 5'-monophosphate, a cytokinin that induces shoot formation on host plants infected with the Ti plasmid [1]. [1]. 1465104. Organization and functional analysis of three T-DNAs from the vitopine Ti plasmid pTiS4. Canaday J, Gerad JC, Crouzet P, Otten L;. Mol Gen Genet 1992;235:292-303. (from Pfam)

Date:

2024-10-16

This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37) [2]. [1]. 9294434. The modified nucleoside 2-methylthio-N6-isopentenyladenosine in tRNA of Shigella flexneri is required for expression of virulence genes. Durand JM, Bjork GR, Kuwae A, Yoshikawa M, Sasakawa C;. J Bacteriol 1997;179:5777-5782. [2]. 8139535. Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol. Boguta M, Hunter LA, Shen WC, Gillman EC, Martin NC, Hopper AK;. Mol Cell Biol 1994;14:2298-2306. [3]. 1850093. MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA. Gillman EC, Slusher LB, Martin NC, Hopper AK;. Mol Cell Biol 1991;11:2382-2390. (from Pfam)

Date:

2024-10-16

tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

Date:

2024-07-02

Alternate names include delta(2)-isopentenylpyrophosphate transferase, IPP transferase, 2-methylthio-N6-isopentyladenosine tRNA modification enzyme. Catalyzes the first step in the modification of an adenosine near the anticodon to 2-methylthio-N6-isopentyladenosine. Understanding of substrate specificity has changed.

Gene:

miaA

Date:

2021-04-27