Protein Family Models for Protein (Select 495005795) - Protein Family Models

Select item 4284781.

Arabinosyltransferase concanavalin like domain

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. [1]. 8876238. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM;. Proc Natl Acad Sci U S A 1996;93:11919-11924. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF036975.5
Method:: HMM

Select item 4239392.

arabinosyltransferase C-terminal domain-containing protein

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate [2]. [1]. 8876238. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM;. Proc Natl Acad Sci U S A 1996;93:11919-11924. [2]. 21383969. The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. Alderwick LJ, Lloyd GS, Ghadbane H, May JW, Bhatt A, Eggeling L, Futterer K, Besra GS;. PLoS Pathog. 2011;7:e1001299. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF026246.5
Method:: HMM

Select item 4143073.

arabinosyltransferase domain-containing protein

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. [1]. 8876238. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM;. Proc Natl Acad Sci U S A 1996;93:11919-11924. (from Pfam)

GO Terms:

Molecular Function:: arabinosyltransferase activity (GO:0052636)

Biological Process:: Actinobacterium-type cell wall biogenesis (GO:0071766)

Date:: 2024-10-16

Family Accession:: NF016484.5
Method:: HMM

Select item 4032554.