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Links from Protein

Items: 5

1.

type II CAAX prenyl endopeptidase Rce1 family protein

This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologues in all three domains of life, including Rce1 from S. cerevisiae [1]. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases [2]. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis [3]. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs [4]. There is a conserved sequence motif EExxxR. [1]. 20154137. The abi proteins and their involvement in bacteriocin. self-immunity.. Kjos M, Snipen L, Salehian Z, Nes IF, Diep DB;. J Bacteriol. 2010;192:2068-2076.. [2]. 29424242. Rce1: mechanism and inhibition.. Hampton SE, Dore TM, Schmidt WK;. Crit Rev Biochem Mol Biol. 2018;53:157-174.. [3]. 16361710. Mutational analysis of the ras converting enzyme reveals a. requirement for glutamate and histidine residues.. Plummer LJ, Hildebrandt ER, Porter SB, Rogers VA, McCracken J,. Schmidt WK;. J Biol Chem. 2006;281:4596-4605.. [4]. 24291792. Mechanism of farnesylated CAAX protein processing by the. intramembrane protease Rce1.. Manolaridis I, Kulkarni K, Dodd RB, Ogasawara S, Zhang Z, Bineva. G, Reilly NO, Han. TRUNCATED at 1650 bytes (from Pfam)

GO Terms:
Cellular Component:
membrane (GO:0016020)
Molecular Function:
glutamic-type endopeptidase activity (GO:0070007)
Date:
2024-08-14
Family Accession:
NF014566.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.

JDVT-CTERM system glutamic-type intramembrane protease

JDVT-CTERM system glutamic-type intramembrane protease is a homolog of eukaryotic type II CAAX prenylation site proteases, which proteolytically remove C-terminal residues of farnesylated and geranylated proteins

Date:
2023-08-07
Family Accession:
14337512
Method:
Sparcle
4.
new record, indexing in progress
Family Accession:
5.

JDVT-CTERM system glutamic-type intramembrane protease

See NF033191.

Gene:
mrtJ
GO Terms:
Biological Process:
protein targeting (GO:0006605)
Molecular Function:
glutamic-type endopeptidase activity (GO:0070007)
Date:
2024-05-10
Family Accession:
NF033192.3
Method:
HMM
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