Protein Family Models

This family of proteins contains MlaD, which is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane [1]. The family also contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage [2]. This family contains proteins of unknown function from other bacteria. [1]. 19383799. An ABC transport system that maintains lipid asymmetry in the. gram-negative outer membrane.. Malinverni JC, Silhavy TJ;. Proc Natl Acad Sci U S A. 2009;106:8009-8014.. [2]. 8367727. Cloning of an M. tuberculosis DNA fragment associated with entry. and survival inside cells [see comments]. Arruda S, Bomfim G, Knights R, Huima-Byron T, Riley LW;. Science 1993;261:1454-1457.. [3]. 10474190. Disruption of the mycobacterial cell entry gene of Mycobacterium. bovis BCG results in a mutant that exhibits a reduced. invasiveness for epithelial cells.. Flesselles B, Anand NN, Remani J, Loosmore SM, Klein MH;. FEMS Microbiol Lett 1999;177:237-242. (from Pfam)

Date:

2024-08-14

MlaD family protein similar to MlaD, which is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane, and to mce (mammalian cell entry) proteins from Mycobacterium tuberculosis, virulence proteins required for invasion of non-phagocytic cells

Date:

2024-08-26