Protein Family Models

The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. [1]. 8626329. Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus. Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RM;. J Bacteriol 1996;178:2605-2612. [2]. 15784968. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S;. Biosci Biotechnol Biochem. 2005;69:431-439. (from Pfam)

Date:

2024-10-16

DJ-1/PfpI family protein, similar to Escherichia coli YajL, a covalent chaperone that protects cells against protein sulfenylation

Date:

2018-05-31

Members of this family, found in bacteria and eukaryotes, include human DJ-1, product of the PARK7 (Parkinson disease protein 7) gene, previously called a deglycase but now called a glyoxalase III. Many members of the DJ-1 clade have been annotated (apparently incorrectly) as ThiJ, a protein of thiamine biosynthesis. However, published reports of ThiJ activity and identification of a ThiJ/ThiD bifunctional protein describe an unrelated locus mapping near ThiM, rather than the DJ-1 homolog of E. coli. Glyoxalase III detoxifies methylglyoxal by a one-step conversion to D-lactate, and does not require glutathione.

Date:

2023-11-04