Protein Family Models

A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1]. This family appears related to the N-terminal domain of phage integrases. [1]. 20532204. Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families. Ellrott K, Jaroszewski L, Weizhong L, Wooley J, Godzik, A. PLoS Computational Biology, 2010 (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

Date:

2024-10-16

Tsr15 (tyrosine site-specific recombinase 15), as the term is used in Bacteroides fragilis NCTC 9343, is one of at least four tyrosine-type DNA invertases.

Date:

2020-07-22

tyrosine-type recombinase/integrase cleaves DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment.

Date:

2024-04-09