Protein Family Models

Experiments on the YhhW protein show that is has quercetinase activity. This entry represents the C-terminal cupin domain from the two cupin domains that make up the protein [1]. This domain is usually associated with Pfam:PF02678. [1]. 15951572. Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, Jia Z;. J Biol Chem. 2005;280:28675-28682. [2]. 18561187. The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins. Gurmu D, Lu J, Johnson KA, Nordlund P, Holmgren A, Erlandsen H;. Proteins. 2009;74:18-31. (from Pfam)

Date:

2024-10-16

This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within dot-like subnuclear structures [1]. A tomato homologue of human Pirin has been found to be induced during programmed cell death [2]. Human Pirin interacts with Bcl-3 and NFI [3] and hence is probably involved in the regulation of DNA transcription and replication. It appears to be an Fe(II)-containing member of the Cupin superfamily. [1]. 9079676. Identification of pirin, a novel highly conserved nuclear protein. Wendler WM, Kremmer E, Forster R, Winnacker EL;. J Biol Chem 1997;272:8482-8489. [2]. 11485202. A tomato homologue of the human protein PIRIN is induced during programmed cell death. Orzaez D, de Jong AJ, Woltering EJ;. Plant Mol Biol 2001;46:459-468. [3]. 10362352. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A;. Oncogene 1999;18:3316-3323. [4]. 14573596. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. Pang H, Bartlam M, Zeng Q, Miyatake H, Hisano T, Miki K, Wong LL, Gao GF, Rao Z;. J Biol Chem 2004;279:1491-1498. (from Pfam)

Date:

2024-10-16

pirin family protein contains a bicupin domain, similar to quercetin 2,3-dioxygenase, a copper-containing enzyme that catalyzes the insertion of molecular oxygen into polyphenolic flavonols

Date:

2024-09-20