Protein Family Models

WYL_2 is a family of Sm-like SH3 beta-barrel fold containing domains. WYL is named for three conserved amino acids found in a subset of domains of this superfamily. These residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine [1], which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system [1] [1]. 24817877. CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems. Makarova KS, Anantharaman V, Grishin NV, Koonin EV, Aravind L;. Front Genet. 2014;5:102. (from Pfam)

Date:

2024-10-16

WYL_2 domain-containing protein

Date:

2019-03-21