Protein Family Models

This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold. (from Pfam)

Date:

2024-08-14

Pathogenic Neisseria spp. possess a repertoire of phase-variable Opacity proteins that mediate various pathogen--host cell interactions [2]. These proteins are integral membrane proteins related to other porins. [1]. 3093085. Opacity genes in Neisseria gonorrhoeae: control of phase and antigenic variation. Stern A, Brown M, Nickel P, Meyer TF;. Cell 1986;47:61-71. [2]. 10036728. The role of neisserial Opa proteins in interactions with host cells. Dehio C, Gray-Owen SD, Meyer TF;. Trends Microbiol 1998;6:489-495. (from Pfam)

Date:

2024-10-16

This family includes a number of bacterial surface antigens expressed on the surface of pathogens. [1]. 8294020. Derivation of the complete msp4 gene sequence of Anaplasma marginale without cloning. Oberle SM, Barbet AF;. Gene 1993;136:291-294. [2]. 9573188. Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis. Braig HR, Zhou W, Dobson SL, O'Neill SL;. J Bacteriol 1998;180:2373-2378. (from Pfam)

Date:

2024-10-16

A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus.

Date:

2024-06-21

outer membrane protein containing beta-barrel domain, such as Salmonella enterica outer membrane protein PagN, an adhesin and invasin, that mediates invasion via interaction with proteoglycan

Date:

2024-08-26