Methyltrans_16 is a lysine methyltransferase. Characterised members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins [2,3,4,5]. [1]. 12872006. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, Dlakic M, Clarke S;. Mol Cell Proteomics 2003;2:525-540. [2]. 20975703. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Magnani R, Dirk LM, Trievel RC, Houtz RL;. Nat Commun. 2010;1:43. [3]. 22948820. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, Davydova E, Jakobsson M, Moen A, Pettersen S, Maelandsmo GM, Egge-Jacobsen W, Falnes PO;. Nat Commun. 2012;3:1038. [4]. 23349634. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M, Coulombe B;. PLoS Genet. 2013;9:e1003210. [5]. 23921388. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PO;. J Biol Chem. 2013;288:27752-27763. (from Pfam)
- Date:
- 2024-10-16