This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyses the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG) [1,3]. This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production [2]. [1]. 14769468. MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance. Staubitz P, Neumann H, Schneider T, Wiedemann I, Peschel A;. FEMS Microbiol Lett. 2004;231:67-71. [2]. 19649276. The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides. Maloney E, Stankowska D, Zhang J, Fol M, Cheng QJ, Lun S, Bishai WR, Rajagopalan M, Chatterjee D, Madiraju MV;. PLoS Pathog. 2009;5:e1000534. [3]. 30563904. Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance. Ernst CM, Slavetinsky CJ, Kuhn S, Hauser JN, Nega M, Mishra NN, Gekeler C, Bayer AS, Peschel A;. mBio. 2018; [Epub ahead of print] (from Pfam)
- Date:
- 2024-10-16