Protein Family Models

This entry represents the glycoside hydrolase domain found at the C-terminal of Mannosylglycerate hydrolase MGH1 and similar sequences. Paper describing PDB structure 1v7v. [1]. 15274915. Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold. Hidaka M, Honda Y, Kitaoka M, Nirasawa S, Hayashi K, Wakagi T, Shoun H, Fushinobu S;. Structure. 2004;12:937-947. Paper describing PDB structure 2jf4. [2]. 17455176. Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors. Gibson RP, Gloster TM, Roberts S, Warren RA, Storch de Gracia I, Garcia A, Chiara JL, Davies GJ;. Angew Chem Int Ed Engl. 2007;46:4115-4119. Paper describing PDB structure 2okx. [3]. 17936784. Crystal structure of glycoside hydrolase family 78 alpha-L-Rhamnosidase from Bacillus sp. GL1. Cui Z, Maruyama Y, Mikami B, Hashimoto W, Murata K;. J Mol Biol. 2007;374:384-398. Paper describing PDB structure 3d3i. [4]. 18586271. Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63. Kurakata Y, Uechi A, Yoshida H, Kamitori S, Sakano Y, Nishikawa A, Tonozuka T;. J Mol Biol. 2008;381:116-128. Paper describing PDB structure 3qde. [5]. 22102229. Structure of cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate. Bianchetti CM, Elsen NL, Fox BG, Phillips GN Jr;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1345-1349. [6]. 28329766. Complex pectin metabolism by gut bacteria reveals novel catalyti. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-21

This domain is found at the N-terminal end of Glucosidase YgjK from Escherichia coli and similar bacterial enzymes from the glycoside hydrolase family 63 (GH63) from bacteria, archaea, and eukaryotes. YgjK is organised into N- and A- domains and a linker between them. This entry includes the N-domain and the linker. The N-domain is composed of 18 antiparallel beta-strands divided into two beta- sheets and is classified as a super-beta-sandwich. The linker is composed of two helices and produces a significant curvature between the two domains [1-3]. Paper describing PDB structure 3d3i. [1]. 18586271. Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63. Kurakata Y, Uechi A, Yoshida H, Kamitori S, Sakano Y, Nishikawa A, Tonozuka T;. J Mol Biol. 2008;381:116-128. Paper describing PDB structure 3w7w. [2]. 23826932. Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity. Miyazaki T, Ichikawa M, Yokoi G, Kitaoka M, Mori H, Kitano Y, Nishikawa A, Tonozuka T;. FEBS J. 2013;280:4560-4571. Paper describing PDB structure 6xux. [3]. 33408403. Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Uchanski T, Masiulis S, Fischer B, Kalichuk V, Lopez-Sanchez U, Zarkadas E, Weckener M, Sente A, Ward P, Wohlkonig A, Zogg T, Remaut H, Naismith JH, Nury H, Vranken W, Aricescu AR, Pardon E, Steyaert J;. Nat Methods. 2021;18:60-68. (from Pfam)

Date:

2024-10-16

Gene:

ygjK

Date:

2021-09-01

alpha-glucosidase similar to Escherichia coli YgjK

Date:

2015-10-23