This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterised as a deazaflavin-dependent nitroreductase [1, 2]. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection [3]. [1]. 16387854. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Manjunatha UH, Boshoff H, Dowd CS, Zhang L, Albert TJ, Norton JE, Daniels L, Dick T, Pang SS, Barry CE 3rd;. Proc Natl Acad Sci U S A. 2006;103:431-436. [2]. 19039139. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd;. Science. 2008;322:1392-1395. [3]. 23240649. A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents. Gurumurthy M, Rao M, Mukherjee T, Rao SP, Boshoff HI, Dick T, Barry CE 3rd, Manjunatha UH;. Mol Microbiol. 2013;87:744-755. (from Pfam)
GO Terms:- Molecular Function:
- oxidoreductase activity (GO:0016491)
- Date:
- 2024-10-16